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Speakers - Kleber Thiago de Oliveira

Invited lecture

Combining batch and continuous flow setups in the end-to-end synthesis of naturally occurring curcuminoids, and photo-larvicidal effects against Aedes aegypti Larvae.

Kleber Thiago de Oliveira

1 Department of Chemistry, Federal University of São Carlos – UFSCar, Rod. Washington Luiz km 235, São Carlos-SP, 13.565-905, www.lqbo.ufscar.br, *kleber.oliveira@ufscar.br

Curcumin and its natural derivatives are present in turmeric (Curcuma longa), and are traditionally used as coloring in cooking [1]. Recently, curcuminoids have been shown to have numerous applications in medicinal chemistry and in photonic therapies, due to their excellent activities as drugs and as photosensitizers. Herein, we present an approach for the end-to-end synthesis of curcumin and two other natural curcuminoids all synthesized by the same integrated protocol [1]. A telescoped approach under continuous flow conditions has been developed and compared to the combined flow–batch and all batch systems, demonstrating the combined flow-batch approach more cost effective. In addition, recent and relevant photo-larvicidal results against Aedes aegypti larvae will be presented, showing that the combination of curcuminoid pigments with sunlight establishes an extremely effective alternative for larvae control, and with high environmental safety and low persistence of these molecules.

 

[1] Carmona-Vargas, C. C.; Alves, L. C.; Brocksom, T. J.; de Oliveira, K. T. React. Chem. Eng. 2, 366, 2017.