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Speakers - Edson Rodrigues-Filho

Type of the Presentation: (Short lecture)

 

 “THE ROLE OF ENDOPHYTIC MICROORGANISMS IN THE STRUCTURAL DIVERSIFICATION OF TERPENOIDS”

 

Edson Rodrigues-Filho1

 

1  Chemistry Department – Universidade Federal de São Carlos; edinho@pq.cnpq.br

 

The natural products can have molecular structures with a fantastic architecture, mostly resulted from the action of diverse enzymes in simple starting molecules. While the initial steps in the biosynthetic routes of these substances are in the majority already well known, the actors of the posterior structural modifications are of difficult recognition and generally are attributed to catabolic processes. It has already an ample acceptance that microorganisms can coexist with plants during all its seasonal cycles. Literature data seem to corroborate the hypothesis that in many cases it is possible that enzymes of different origin can participate in a supposed “cooperative biosynthesis” between plants and microorganisms, that would result in poli-functionalized natural products molecules. Thus, the efforts made in the Laboratório de Bioquímica Micromolecular de Microorganismos (LaBioMMi), Depto. of Chemistry at UFSCar, aim at contributions in understanding the accumulation of important natural products in vegetal tissues. In this stage, we are isolating endophytic microorganisms from terpenoid accumulating plants and try to verify the production of terpenoids by these endophytes. Abundant terpenes isolated from endophyte host plants are submitted to microbiological structural modifications. The biochemical intimacy developed during the interactions between plants and microorganisms may serves as a good guide to find useful enzyme capable of to transform natural products isolated from microorganisms host plant and their synthetic analogues, generating bioactive substances.

The many results we got so far support the hypothesis that the endophytic microorganisms possibly participate in the terpenoid oxidation in plant, acting as a putative member of a biosynthetic consortia.