Speakers - Alvaro E. Eiras

Type of the Presentation: (Short lecture)


CHEMICAL Ecology of Aedes aegypti: From the laboratory bench to the society


Alvaro E. Eiras.

Chemical Ecology of Vector Borne Disease Laboratory, Department of Parasitology, ICB, Universidade Federal de Minas Gerais, Brazil (UFMG) (alvaro.eiras@gmail.com)


Dengue, Chikungunya, Zika and recently the yellow fever, are the infectious diseases caused by the virus that are transmitted by the bite of the female mosquito Aedes aegypti (Diptera: Culicidae). These diseases are considered a major public health problem in Brazil and in Americas. Monitoring adult Ae. aegypti abundance with fixed position traps has been proved to be an alternative surveillance method that shows cost-benefit for directing vector control and predicting when and where dengue outbreaks will take place. Such mosquito traps rely on olfactory and visual cues. The olfactory cues consist of synthetic attractants for host seeking and gravid Ae. aegypti mosquitoes, were developed in laboratories from the UFMG (Brazil) and University of Regensburg (Germany) and UFMG, respectively. Both university launched two “spin-off” companies that developed products to the market and has been used worldwide for over a decade with successful results. The host seeking Ae. agypti is attracted by synthetic human odour (lactic acid, hexanoic acid and ammonia) and incorporated into novel trap designs ("BG-Sentinel trap"). New formulated for controlled release ("BG-Lure") and BG-Sentinel trap has been successfully used for mass trapping the dengue vector in Brazil and in Italy. Oviposition attractants for gravid Ae. aegypti (AtrAedes) were extracted and identified from grass infusions by means of a combination of studies using electrophysiology (electroantennography), gas-chromatography coupled with mass-spectrometry (GC-MS), gas-chromatography coupled with electroantennography (GC-EAD) and behaviour studies in laboratory, semi-field and field studies. The compounds identified were patented. Here in, examples of simple production of lures in small scales will be presented as an example of small scale in laboratory and a mass production by machinery. AtrAedes has been used in the field over 12 years in a successful monitoring dengue vector technology (MI-Aedes). The MI-Aedes consists of an integration of continuous vector monitoring, at fine spatial and temporal scales, and information technology platform for near real-time data collection, analysis, and decision-making. The surveillance data generated from the system is used to calculate weekly vector indices and easily discernible geographical hot spots to target vector control resources. Such technology has been used over 120 Brazilian cities, more than 32,000 traps, 450 thousands of lures in areas with about 10 million people. Both examples of semiochemicals illustrated above clearly show the importance of studies from laboratory bench to the society by providing employment, royalties to the university, taxis and essentially benefit public health.


Financial support: CNPq, FAPEMIG, FINEP, SEBRAE