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Abstracts - Carlos F. Moraes

WATER-SOLUBLE PEPTIDE COPPER(II) COMPLEXES: A NEW APPROACH IN THE SEARCH OF PESTICIDE COMPOUNDS

Carlos F. Moraes1* , Wilmer Villarreal1 and Maria Fátima das G. F. da Silva1 1 Universidade Federal de São Carlos, São Paulo, Brasil

* Correspondence: andre453_@hotmail.com

Copper is a micronutrient essential to all organisms living in oxygen-rich environments. In biology, copper is crucial for the function of several enzymes and proteins involved, among others, in energy metabolism, mitochondrial respiration (e.g. cytochrome oxidase; Cco), antioxidation (e.g. Zn,Cu-super-oxide dismutase; SOD), collagen cross- linking (e.g. lysil oxidase), pigmentation (e.g.tyrosinase), and cathecolamine biosynthesis (e.g. dopamine-b-monooxygenase).1 On the other hand, the peptides are important biomolecules, present in the principal biologic system, building the proteins, which are chemical species indispensable to perform a large number of biological functions.2 The variability of bioactive compounds, their relationship with genetic and climatic factors, changes in their concentration are factors that modified the incidence of several citrus physiological diseases, 3 for this reason we decided combinate biomolecules as peptides with the biologic properties of copper metal center with the finality of development new pesticide compounds.

 

Refs. 1. Tisato, F. et al. Med. Res. Rev, 30, 708, 2010. 2. Stanila, A. et al. Journal of Molecular Structure, 834: 364, 2007. 3. Santos Soares, M. et al. Phytochemistry, 115, 161, 2015.